Effects of divorce on children Research Proposal

Effects of divorce on children - Research Proposal Example (Clark-Stewart, 2007) In this regard, it is very important that core principles should be taught to the people of American society, which will help in achieving a potential and mature individual. Divorce of a number of parents is resulting in suffering of more than a million children in the United States. Moreover, studies have indicated that every year, half of children’s population suffers effects of divorce around the country. Evidence related to social science has shown that present and future generations of society are affected socially, economically, emotionally, as well as, physically by devastating effects of divorce. In brief, this paper will try to define, discuss, and analyze some of the aspects of divorce that affects the children. Statistics have specified that an increasing number of children are reported to be involved in different cases of abuse, who were living with divorced parents. More emotional and behavioral problems are exhibited by such children, who are an important part of human society. Moreover, higher frequency in drug abuse and crime has been reported with children living with single divorced parent. (Clark-Stewart, 2007) In educational terms, reading, math, and spelling are some subjects that are severely affected after divorce of the parents. In some of the states, lower rates of college graduation are observed in children with divorced parents. In other words, divorce affects the children on intellectual platform as well, which is responsible for significant development of the society. Additionally, fifty percent drop in grades is observed in children that experience divorce of their parents, as compared with their grades before the divorce. Eighty-five percent of adolescents have reported state of loneliness after the divorce, which shows the emotional effect of divorce on the children. Religion is an important aspect of human life, which has been associated with a number of activities, and studies have shown that

Changes in Social Lending Essay Example | Topics and Well Written Essays - 250 words

Changes in Social Lending - Essay Example dit permits very underprivileged people to insert themselves into projects that are focused on self-employment— with a view of generating some income. Yunus provides loans through his controversial bank, Grameen Bank—which makes him a pioneering single leader. Grameen Bank based in Bangladesh lends money through solitary groups. The bank’s approaches targets solitary groups as its prime building block. Further, the use of this technique has clearly had a significantly positive effect upon many prospective borrowers. Without Grameen, the financially handicapped wouldn’t have dared borrowing at all. I mean, to many of them, borrowing would figuratively be building castles in the air. Be that as it may, the determination to warranty that all members of solidarity groups are equally poor is inconsistent, and may not always improve the group performance at all. In all, microcredit is mere bunkum—in fact; it won’t succeed without the help of immense grants. In all, this is a reality that dents on the development of this approach. Conversely, this approach lacks clear lucidity. Glancing at it through perspectives, the overall effect of this development approach has not been to reduce poverty, but only to produce a debt gridlock for gullible borrowers—who are incredulously subjected to particularly supercilious rates of interests practical to conventional banks . It is no surprise at all that Yunus used the infused poverty in his country profitably to gain international attention. This approach of bottom of the pyramid has no capability of finally leading to long-term development, because many poor people will feel that they are being defrauded through the obviously feasible

Business plan for a start-up ( Financial data) Literature review

Business plan for a start-up ( Financial data) - Literature review Example With god business plan, the future of the business is certain and all future occurrences will be met with certainty. For a stat-up business, plan is used by business to determine its future survival and viability. Businesses cannot run effectively without a plan. Most plan make assumptions about the future. Any assumption made should be made with great caution as failure for the assumption to hold, the whole plan might be jeopardized. A successful business plan should be prepared based on past experiences fact and empirical data. It requires lo of expertise to prepare a concrete plan for a start-up business that has no past records experience. This paper will focus on the financial side of a business plan by reviewing overall financial records for all industries that are components of a plan. The financial plan of a start-up business will be based on the size of the proposed business. This means that it will rely mainly on assumptions. Analysis will be done o the future cash flows, i ncomes and expenses, balance sheet, capital, profitability and financial ratio analysis. The major assumption that will be used in the plan will be: The prevailing market and economic conditions prevail. Methodology The plan will be prepared based on projection of financial statements. ... According to Lemieux (2013), The various parameters that have taken into consideration for evaluation of the net income of the firms are the general, selling and administrative expenses, depreciation, regulatory expense, insurance costs of the company, rental charges to be paid for the establishment of the business, cost of advertising, utility bills, etc (Lemieux, 2013, p.39). These expenses are adjusted to the gross earnings to form the net earnings of the company. The net earnings of the company are important for the calculation of the net operating cash flows. The net operating cash flow has been forecasted to be 35500 pounds which is expected to increase gradually in the next two years. There are investment cash flows for firms which would involve cash outflows for purchase of fixed assets of the company and other capital expenditures. The cash out flows on account of investment activity of the business is valued at 16250 pounds. The investment activities are expected to increas e in the first three years as the business would focus on increasing their market share. The cash outflows due to financing activities would be due to the interest payment for the debt incurred from the bank and the interest paid to the creditors. The cash outflow for financing activities of the business would be 15650 pounds that is anticipated to increase in the next two years. The net cash flows for the business have been forecasted to be 3600 pounds which is expected to increase by 10% in the next two years as shown in Table 4 in the Appendix. Uses of the data The profit and loss statement and the balance sheet have been forecasted as a part of the business plan and have been presented in Table 2 and Table 3 respectively in the

Image ethics, Image editing Research Paper Example | Topics and Well Written Essays - 1750 words

Image ethics, Image editing - Research Paper Example The deception commonly occurs because of the increased idolization and desire for individuals to possess pictures of celebrities. Personal pictures of celebrities might be difficult to access, but the editing technology can be utilized to gain an image of a much adored celebrity. While this technology remains commonly utilized among many media, ethical questions continue to arise regarding the application of the technology. Despite the numerous prevailing ethical issues surrounding application of the technology, laws seeking to prevent the utilization of the technology continue to become continuously silenced. This continues to be contributed by the numerous advantages of the technology upon the industry. A comparison between the contributions of the technology upon photography and the existing negativity of the technology indicates the technology might not be eliminated. Introduction Image editing remains a technology that has been applied since the introduction of photography itsel f. ... This activity has become a pastime occupation for many individuals as it continues to gain popularity in the modern world. In fact, the practice, though unaccepted by the creators of Photoshop software, has almost become accepted as a modern form of visual art. Importance of image editing Image editing is performed for different reasons, which remain fundamentally focused on enhancing satisfaction to the owners of the image. Within the print media, editing of images is commonly performed as a method for improvement of image quality (Anders and Benson, 117). Some photos taken by journalists are taken within extremely difficult conditions and might be distorted. The need to present clear pictures necessitates utilization of editing to enhance the quality. Through editing, blurred images can be clarified to give them definite outlines, consequently improving image clarity (Lister, 75). The editing technology remains fundamental in making essential conversions of images to digital form s. This conversion has enabled quick and easy transferring of images between different locations, while retaining original image aspects and appearance. The digital era continues to bring numerous aspects of modern imagery through the utilization of technological methods in production of images. The application of image editing technology remains essential in ensuring easy acquisition of images as required. The technology has provided the press with a quick and fast method for transferring images from different locations (Anders and Benson, 145). Through image editing publication, costs become extremely reduced, while making publication quick. This has continuously enabled larger and quick circulation of periodic publications especially newspapers. The presence of editing software has

Developing a conceptual framework is an impossible possibility Essay - 1

Developing a conceptual framework is an impossible possibility - Essay Example There have been increasing efforts towards formation of standardized approaches in accounting, in what may be explained to be an accounting conceptual framework. The standardized approach in accounting aims to offering a holistic and uniformed approach in which all accounting problems can be handled. Moreover, such standards help in ensuring ethics and morality in accounting discipline considering that fraud and dishonesty are the main vices affecting the economic discipline as people undertake such economic roles with selfish interests, eroding the integrity of such a profession. Knowledge regarding elements and aspects of accounting and the image created by such profession are thus of critical importance in accounting. Knowledge and Sources of Knowledge Epistemology is the discipline concerned with the theory of knowledge and the way people can attain knowledge. In most cases, sentences are only used to convey meaning, and the meaning itself does not reside in sentences. A proposit ion is the main element in a sentence as it refers to the meaning of a sentence, and it is the one that leads to knowledge. In accounting, knowledge can be gained from a diversity of sources. Knowledge may be attained through skills in doing something. An accountant who spends most of the time preparing financial statement will develop skills in the practice and this would lead to more detailed knowledge than other accountants in a separate department. This involves the act of â€Å"knowing how† to do something. Moreover, such knowledge may be genetically programmed in that some people are born with talents and have much higher proficiency in carrying out specific tasks. Knowledge may also be obtained through acquaintance with something or observing something until one grasps the basic concepts in doing it. For example, as person can observe the basic operation of balancing a balance sheet, or any other financial statement over time till they grasp the basic concepts of perfo rming such a task even without formal education on how to do it. Many people in on-job training learn through acquaintance till they develop such skills and are able to perform as required. Knowledge may also be obtained through understanding statements in an inductive reasoning approach. For example, one may gain knowledge by first appreciating the fact that a financial statement has to convey the truth about a company. Therefore, one has to develop a belief regarding the truth conveyed in such a financial statement, and then look for some good facts as evidence to prove the belief is true. However, it must be recalled that truth has to remain as truth despite one knowing it or not, and is not influenced with such inductive reasoning. Knowledge and truth are thus independent of one another and one requires deeper investigation to determine if such knowledge really leads to reality or truth. Accounting Theories Hendrickson (1970) defines a theory as a set of coherent hypothetical, p ragmatic and conceptual principles that guide in the field of inquiry (as cited in Deegan and Unerman, 2009). The use of the word coherence indicates that all the elements in a theory have to work together in presenting a certain knowledge, or result in accounting. However, Deegan and Unerman (2009) noted that theories

Portable Players Essay Example for Free

Portable Players Essay The innovation set by the Walkman has lead to the creation of different portable media for music listening. This paved the way for the consumers to forever change the way they listen to music (Bellis 1). In fact, the Walkman is considered to be the main catalyst which prompted many companies to re-invent their products to become handy and mobile. Previously, music and news were only confined in big mechanical boxes sitting inside a living room. No one ever imagined that a bulky listening device can actually be turned into something which will fit right into one’s pocket. The Walkman, with an offshoot of portable CD players, has greatly modified the way people establish their lifestyles. The establishments of portable media players, especially those which can play music, have increased a form of mobility for consumers. Practically, it is very obvious that people are now freer to work on other matters even while listening to their favorite tunes. For most cases, this can equate to greater productivity values in day to day activities. Moreover, having a portable listening device such as a CD player makes one’s feelings more invigorated. This can deliberately affect his outlook towards the tasks he is going to do. Aside from that, it is very likely that the convenience of having a portable media player can increase the ability of a person to interact with other people. On a personal note, the presence of portable listening devices is actually a two-faceted situation. On the positive side, people now have the option to bring along the music wherever they go and whenever they may demand for it. Portable media have truly become one convenient way to integrate an entertainment platform defying the limits of previous generations of bulky and impractical music devices. This enriches a person’s point of view because of the fact that he can actually make his life enjoyable by listening to his favorite music anytime. On the other side however, having portable media can actually spell some drastic effects towards an individuals’ personality especially when the use of such devices become uncontrollable. One reason why mobile music players have a positive effect to a person’s social life is the fact that they can satisfy the personal needs of people. For example, if one needs to relax a bit out of the daily routine work, then a simple click and popping of headsets to the ears would sustain a change in mood for the better (Weinberger 1). However, it is also possible that such person, with the right addiction level towards music, may forget that he is still actually a part of the greater social structure. It is very possible that he will tend to interact less and less with other people, become unproductive at work or even modify an attitude towards obsession. Add to that the fact that portable music players pose a certain degree of health risks. Personal stereo systems may actually induce hear loss with extended use according to Canada’s Minister of Health. Even the Media Awareness Network is concerned about having music which promotes racism, discrimination and violence which makes it more available to portable players. Technology is one of the main factors for the development of human society. But sometimes, there are also some consequences that it may induce for people to change their outlook in life, personal feelings and overall philosophy. In such a case, it is important that each person has the capacity to limit himself towards becoming a slave for technological advancement in which social interaction perspectives maybe compromised. As of the moment, the portable music players are still doing its job to satisfy the entertainment hunger of the people. It is only a matter of personal evaluation to help an individual look beyond the excitement of having a mobile music treasure box and see other consequences it may bring. Works Cited Bellis, Mary. Sony Walkman. About. com. 2008. 27 Feb 2008 http://inventors.about. com/od/wstartinventions/a/Walkman. htm. Health Canada, Its Your Health. Minister of Health. 2006. Her Majesty the Queen in Right of Canada. 27 Feb 2008 http://www. hc-sc. gc. ca/iyh-vsv/life-vie/stereo-baladeur_e. html. Media Awareness, Inappropriate Content in Music. Media Awareness Network. 2008. 27 Feb 2008 http://www. media-awareness. ca/english/parents/music/inappropriate/negative_effects_music. cfm. Weinberger, Norman. Musica Research Notes. Musica. uci. edu. 1996. 27 Feb 2008 http://www. musica. uci. edu/mrn/V3I1S96. html#coloring.

B Cell Activation in HIV Infection

B Cell Activation in HIV Infection During HIV infection, B cells can be activated by HIV virions, plasmacytoid dendritic cells, infected macrophages and CD40 ligands. Mannose binding lectin (MBL), a C-type lectin, is in a complex with the MASP (MBL-associated serine proteases) enzyme and is involved in recognising and binding carbohydrates on pathogens (e.g. HIV envelope protein gp120 is highly glycosylated). When the carbohydrates are recognised, MBL activates the enzyme activity of MASP which causes the activation of the complement system by cleaving C2 and C4 complements resulting in the formation of C3 convertase. This activation and formation of C3 convertase is known as the alternative pathway of the complement system. C3 complement is cleaved by the C3 convertase enzyme and C3 fragments (C3d/C3dg, iC3b) are formed from this breakdown. These fragments are deposited onto the HIV virion surface. HIV IC (immune complexes) interact with CD21 (complement receptor) on B cells and C3 fragments acts as a mediator in the IC-CD21 interaction. CD21 is involved in the activation of B cells and a constant IC-CD21 activation could trigger the polyclonal a ctivation of B cells in HIV viremia. (1-4) Plasma dendritic cells (pDCs) express TLR9, TLR7, CD4, CCR5, CXCR4 and MCLR receptors. TLR7 receptor is stimulated by its interaction with viral ssRNA and TLR9 by its interaction with unmethylated DNA motifs of the viral genome. Stimulation of these receptors leads to the activation of intracellular pathways both of which involves the activation of the adaptor protein, MyD88. The MyD88-IRF7 pathway involves the activation of IRF7 by MyD88 which goes on to regulate the gene transcription of Type I IFN, leading to Type I IFN production by pDCs. NF-kB is also activated by MyD88 and causes the production of pro-inflammatory cytokines such as TNF-ÃŽ ± and IL-6 by upregulating their gene transcription in pDCs. IFN-ÃŽ ± (a Type l IFN) induces the activation and differentiation of B cells into plasmablasts. The presence of IL-6 causes differentiation of plasmablasts into antibody secreting plasma cells. TNF-ÃŽ ± is involved in the polyclonal activation of B cells. The production of Type I IFN upregulates the mRNA expression of two cytokines involved in stimulating B cells in pDCs. These cytokines cause the activation, proliferation and survival of B cells, immunoglobulin class- switching and are known as BAFF (B cell activating factor) and APRIL (a proliferation-inducing ligand). Both cytokines belong to the tumour necrosis factor (TNF) ligand family. BAFF interacts with B cells by binding to the BAFF receptor (BAFFR) located on the surface of B cells. Plasmacytoid dendritic cells also activate B cells through the interaction of their CD70 ligand with the CD27 receptor on B cells, causing proliferation and differentiation of memory cells into plasma cells. HIV infected macrophages, activate B cells by Nef protein indirectly when it is taken up and expressed de novo by infected macrophages. HIV Nef induces the production of ferritin through the NF-ÃŽ ºB pathway causing gene transcription and releasing ferritin from the infected macrophages. Adequate production of ferritin induces proliferation of resting B cells into antibody secreting plasma cells by upregulating the expression of B cell gene. This activation of B cells can lead to hypergammaglobulinemia the increase in the level of gamma globulins (immunoglobulins) in the blood. (1,20) Figure 1 shows adequate levels of ferritin can lead to increase in immunoglobulin (Ig) levels in the plasma (hypergammaglobulinemia). To determine whether there is a correlation between hypergammaglobulinemia (B cell dysfunction) and plasma ferritin level in HIV infection. Plasma Ig levels were compare to plasma ferritin levels of 83 infected HIV infected people. The results obtained show that there is a positive correlation between plasma ferritin levels and plasma levels of IgA, IgG and IgM in the HIV infected individuals studied. As plasma ferritin levels increased, plasma IgA, IgG and IgM levels also increased generally. (20) The outer layer (envelope) of HIV virions contains viral protein, gp120, which can directly bind to receptors on B cells. Activation of B cells by gp120 causes polyclonal immunoglobulin class switching. This occurs in the presence of BAFF which binds to its receptor on B cells, BAFFR and gp120 binds to MCLRs (mannose-binding C-type lectin receptors) on B cells. The interaction causes IgM to switch to IgG and IgA through the upregulation in the expression of the activation-induced cytidine deaminase, an enzyme involved in class-switch DNA recombination. The HIV gp120 has also been found to inhibit the production of IFN-ÃŽ ± by pDCs by affecting the activation of the TL9 pathway involved in its production. The protein, gp120 binds to CD4, CCR5, CRCR4 and MCLR receptors on pDCs and its binding to CD4 and MCLR has been found to not produce IFN-ÃŽ ± by the TLR9 pathway. This prevents the activation of B cells by the TLR9 pathway through the release of IFN-ÃŽ ±. (7,9,10,21) B cells can also be activated by the interaction between CD40 receptors on B cells and CD40 ligands on T cells in the presence of cytokines (e.g. IL-10). This interaction activates the B cells to differentiate and undergo immunoglobulin class switching by causing class-switch recombination. Class-switch recombination is induced by the activation of NF-kB transcription factor which induces the gene expression of activation-induced cytidine deaminase (AID). However, during HIV infection CD4+ T cells are targets for the HIV virus so number of CD4+ T cells are depleted suppressing this activation of B cells. (22,23) References: Moir, S., Malaspina, A., Li, Y., Chun, T., Lowe, T., Adelsberger, J., Baseler, M., Ehler, L., Liu, S., Davey Jr., R., Mican, J. and Fauci, A. (2000) ‘B Cells of HIV-1–infected Patients Bind Virions through CD21–Complement Interactions and Transmit Infectious Virus to Activated T Cells’, The Journal of Experimental Medicine, 192 (5), pp.637-645. Jakubik, J., Saifuddin, M., Takefman, D. and Spear, G. (2000) ‘Immune Complexes Containing Human Immunodeficiency Virus Type 1 Primary Isolates Bind to Lymphoid Tissue B Lymphocytes and Are Infectious for T Lymphocytes’, Journal Of Virology, 74(1), pp.552-555. Eisen, S., Dzwonek, A. and Klein, NJ. (2008) Mannose-binding lectin in HIV infection, Future Virol., 3(3), pp.225-233 Haurum , JS., Thiel, S., Jones, IM., Fischer, PB., Laursen, SB. and Jensenius, JC. (1993) ‘Complement activation upon binding of mannan-binding protein to HIV envelope glycoproteins.’, AIDS, 7(10), pp.1307-1313 Muraguchi, A., Hirano, T., Tang, B., Matsuda, T., Horii, Y, Nakajima, K. and Kishimoto, T. (1998) ‘ The Essential Role Of B Cell Stimulatory Factor 2 (Bsf-2/Il-6) For The Terminal Differentiation Of B Cells’, J Exp Med, 167, pp.332-344. Jego, G., Palucka, A., Blanck, J., Chalouni, C., Pascual, V. and Banchereau, J. (2003) ‘Plasmacytoid Dendritic Cells Induce Plasma Cell Differentiation through Type I Interferon and Interleukin 6’, Immunity, 19, pp.225-234. Chung, N., Matthews, K., Klasse, P., Sanders, R. and Moore, J. (2012) ‘HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells’, J Immunol, 189(11), pp. 5257- 5265. Shaw, J., Wang, Y., Ito, T., Arima, K. and Liu, Y. (2010) ‘Plasmacytoid dendritic cells regulate B-cell growth and differentiation via CD70.’, Blood, 115, pp.3051–3057. He, B., Qiao, X., Klasse, P., Chiu, A., Chadburn, A., Knowles, D., Moore, J. and Cerutti, A. (2006) ‘HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors.’ J. Immunol, 176, pp.3931–3941. Martinelli, E., Cicala, C., Van Ryk, D., Goode, D., Macleod, K., Arthos, J. and Fauci, A. (2007) ‘HIV-1 gp120 inhibits TLR9-mediated activation and IFN-ÃŽ ± secretion in plasmacytoid dendritic cells.’ Proc Natl Acad Sci USA, 104, pp.3396–3401. Kadowaki, N., Ho, S., Antonenko, S., Malefyt, RW., Kastelein, RA., Bazan, F. and Liu, YJ. (2001) ‘Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.’, J Exp Med, 194 (6), pp.863-870 Lund, J., Sato, A., Akira, S., Medzhitov, R. and Iwasaki, A. (2003) ‘Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells.’, J Exp Med., 198 (3), pp. 513-520 Lund, JM., Alexopoulou, L., Sato, A., Karow, M., Adams, NC., Gale, NW., Iwasaki, A. and Flavell, RA. (2004) ‘Recognition of single-stranded RNA viruses by Toll-like receptor 7.’, Proc Natl Acad Sci USA, 101 (15), pp 5598-5603 Lambert, AA., Gilbert, C., Richard, M., Beaulieu, AD. and Tremblay, MJ. (2008) ‘The C-type lectin surface receptor DCIR acts as a new attachment factor for HIV-1 in dendritic cells and contributes to trans- and cis- infection pathways.’, Blood, 112(4), pp.1299-1307 Jego, G., Palucka, AK., Blanck, JP., Chalouni, C., Pascual, V. and Banchereau, J. (2003) ‘Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6.’, Immunity, 19(2), pp.225-234 Litinskiy, MB., Nardelli, B., Hilbert, DM., He, B., Schaffer, A., Casali, P. and Cerutti, A.(2002) ‘DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL.’, Nat Immunol., 3(9), pp. 822-829 Tezuka, H., Abe, Y., Asano, J., Sato, T., Liu, J., Iwata, M. and Ohteki T. (2011) ‘Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction.’, Immunity, 34(2), pp.247-257 Dai, J., Megjugorac, NJ., Amrute, SB. and Fitzgerald-Bocarsly, P. (2004) ‘Regulation of IFN regulatory factor-7 and IFN-alpha production by enveloped virus and lipopolysaccharide in human plasmacytoid dendritic cells.’, J Immunol., 173(3), pp.1535-48 Cerutti A., Qiao, X. and H, B. (2005) ‘Plasmacytoid dendritic cells and the regulation of immunoglobulin heavy chain class switching.’, Immunol Cell Biol., 83(5), pp.554-562 Swingler, S., Zhou, J., Swingler, C., Dauphin,A., Greenough, T., Jolicoeur, P. and Stevenson, M. (2008) ‘Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS’, Cell Host Microbe, 4(1), pp. 63-76. Geijtenbeek, TB., Kwon, DS., Torensma, R., van Vliet, SJ., van Duijnhoven, GC., Middel, J., Cornelissen, IL., Nottet, HS., KewalRamani, VN., Littman, DR., Figdor, CG. and van Kooyk ,Y. (2000) ‘DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.’, Cell, 100 (5), pp.587-597. Dedeoglu, F., Horwitz, B., Chaudhuri, J., Alt, FW. and S. Geha, RS. (2004) ‘Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkB.’, International Immunology, 16(3), pp.395-404 Qiao, X., He, B., Chiu, A., Knowles, DM., Chadburn, A. and Cerutti, A. (2006) ‘Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells.’, Nature Immunology, 7, pp.302-310 JESSIE FLORENCE GHANSAH